RBM3

Entrez Summary: N/A
UniProt Summary: Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

large ribosomal subunit
small ribosomal subunit rRNA binding
translation repressor activity
ribosomal large subunit binding
positive regulation of mRNA splicing, via spliceosome
poly(U) RNA binding
positive regulation of mRNA processing
positive regulation of RNA splicing
response to cold
mRNA 3-UTR binding
positive regulation of mRNA metabolic process
spliceosomal complex
regulation of mRNA splicing, via spliceosome
positive regulation of translation
negative regulation of translation
regulation of RNA splicing
regulation of mRNA processing
negative regulation of cellular amide metabolic process
positive regulation of cellular amide metabolic process
ribonucleoprotein complex
response to temperature stimulus
regulation of mRNA metabolic process
regulation of translation
regulation of cellular amide metabolic process
dendrite
posttranscriptional regulation of gene expression
nucleolus
RNA processing
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
response to abiotic stimulus
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
positive regulation of cellular protein metabolic process
RNA metabolic process
positive regulation of protein metabolic process
negative regulation of gene expression