RCAN1

Entrez Summary: The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.74
Temozolomide 200μM R04 exp189	2.1

calcium-dependent protein serine/threonine phosphatase regulator activity
calcineurin-NFAT signaling cascade
negative regulation of calcineurin-mediated signaling
negative regulation of calcineurin-NFAT signaling cascade
calcineurin-mediated signaling
inositol phosphate-mediated signaling
negative regulation of calcium-mediated signaling
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
regulation of calcium-mediated signaling
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
calcium-mediated signaling
regulation of phosphatase activity
regulation of dephosphorylation
second-messenger-mediated signaling
blood circulation
circulatory system process
negative regulation of intracellular signal transduction
DNA-binding transcription factor activity
central nervous system development
negative regulation of signal transduction
regulation of hydrolase activity
negative regulation of cell communication
negative regulation of signaling
DNA binding
negative regulation of response to stimulus
intracellular signal transduction
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction
regulation of protein modification process
system process