RDH12 [The Human Chemical-Genetic Interaction Map Project]

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======= RDH12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RDH12
  * **<color #00a2e8>Official Name</color>**: retinol dehydrogenase 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=145226|145226]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96NR8|Q96NR8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RDH12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RDH12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 13 and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments. {ECO:0000269|PubMed:12226107}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Epimerase|
|KR|
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|photoreceptor inner segment membrane|
|cellular detoxification of aldehyde|
|cellular response to aldehyde|
|NADP-retinol dehydrogenase activity|
|retinol dehydrogenase activity|
|photoreceptor cell maintenance|
|retinol metabolic process|
|photoreceptor inner segment|
|retina homeostasis|
|primary alcohol metabolic process|
|cellular detoxification|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|detoxification|
|isoprenoid metabolic process|
|tissue homeostasis|
|hormone metabolic process|
|cellular response to toxic substance|
|visual perception|
|sensory perception of light stimulus|
|alcohol metabolic process|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|organic hydroxy compound metabolic process|
|response to toxic substance|
|regulation of hormone levels|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|sensory perception|
|cellular response to oxygen-containing compound|
|lipid metabolic process|
|nervous system process|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.84|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.95|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5670
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RDH12 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>