RDH12

Entrez Summary: The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 13 and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015].
UniProt Summary: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments. {ECO:0000269|PubMed:12226107}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

photoreceptor inner segment membrane
cellular detoxification of aldehyde
cellular response to aldehyde
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity
photoreceptor cell maintenance
retinol metabolic process
photoreceptor inner segment
retina homeostasis
primary alcohol metabolic process
cellular detoxification
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
detoxification
isoprenoid metabolic process
tissue homeostasis
hormone metabolic process
cellular response to toxic substance
visual perception
sensory perception of light stimulus
alcohol metabolic process
multicellular organismal homeostasis
anatomical structure homeostasis
organic hydroxy compound metabolic process
response to toxic substance
regulation of hormone levels
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
sensory perception
cellular response to oxygen-containing compound
lipid metabolic process
nervous system process
response to oxygen-containing compound
homeostatic process
small molecule metabolic process
system process