RECQL4

Entrez Summary: The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010].
UniProt Summary: DNA-dependent ATPase. May modulate chromosome segregation. {ECO:0000269|PubMed:15317757}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

telomeric D-loop binding
four-way junction helicase activity
annealing helicase activity
oxidized purine DNA binding
telomeric D-loop disassembly
bubble DNA binding
DNA strand renaturation
telomeric loop disassembly
DNA unwinding involved in DNA replication
3-5 DNA helicase activity
helicase activity
chromosome, telomeric region
double-strand break repair via homologous recombination
telomere maintenance
recombinational repair
telomere organization
DNA duplex unwinding
DNA geometric change
DNA-dependent DNA replication
chromosome
double-strand break repair
DNA replication
DNA recombination
DNA conformation change
anatomical structure homeostasis
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
chromosome organization
ATP binding
homeostatic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane