REG1A [The Human Chemical-Genetic Interaction Map Project]

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======= REG1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REG1A
  * **<color #00a2e8>Official Name</color>**: regenerating family member 1 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5967|5967]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05451|P05451]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REG1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REG1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of acinar cell proliferation|
|cellular response to gastrin|
|response to acetylsalicylate|
|response to gastrin|
|pancreas regeneration|
|response to growth hormone-releasing hormone|
|regulation of acinar cell proliferation|
|positive regulation of type B pancreatic cell proliferation|
|zymogen granule|
|cell wall disruption in other organism|
|response to water-immersion restraint stress|
|response to anticoagulant|
|oligosaccharide binding|
|midgut development|
|regulation of type B pancreatic cell proliferation|
|response to platelet aggregation inhibitor|
|basal part of cell|
|peptidoglycan binding|
|positive regulation of dendrite extension|
|regulation of dendrite extension|
|neuronal cell body membrane|
|response to immobilization stress|
|dendrite membrane|
|liver regeneration|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|animal organ regeneration|
|protein phosphatase binding|
|response to chemokine|
|cellular response to chemokine|
|protein homotetramerization|
|antimicrobial humoral response|
|liver development|
|growth cone|
|hepaticobiliary system development|
|digestive tract development|
|transmembrane signaling receptor activity|
|digestive system development|
|protein tetramerization|
|modification of morphology or physiology of other organism|
|regeneration|
|growth factor activity|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|positive regulation of epithelial cell proliferation|
|positive regulation of growth|
|cellular response to peptide hormone stimulus|
|positive regulation of neuron projection development|
|cellular response to peptide|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|protein homooligomerization|
|response to hypoxia|
|response to acid chemical|
|humoral immune response|
|response to decreased oxygen levels|
|positive regulation of neuron differentiation|
|response to oxygen levels|
|positive regulation of cell projection organization|
|response to peptide hormone|
|gland development|
|regulation of cell growth|
|calcium ion homeostasis|
|positive regulation of neurogenesis|
|response to peptide|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|protein complex oligomerization|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|response to wounding|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|ion homeostasis|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|tube development|
|protein homodimerization activity|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REG1A Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>