REG1A

Entrez Summary: This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].
UniProt Summary: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of acinar cell proliferation
cellular response to gastrin
response to acetylsalicylate
response to gastrin
pancreas regeneration
response to growth hormone-releasing hormone
regulation of acinar cell proliferation
positive regulation of type B pancreatic cell proliferation
zymogen granule
cell wall disruption in other organism
response to water-immersion restraint stress
response to anticoagulant
oligosaccharide binding
midgut development
regulation of type B pancreatic cell proliferation
response to platelet aggregation inhibitor
basal part of cell
peptidoglycan binding
positive regulation of dendrite extension
regulation of dendrite extension
neuronal cell body membrane
response to immobilization stress
dendrite membrane
liver regeneration
antimicrobial humoral immune response mediated by antimicrobial peptide
animal organ regeneration
protein phosphatase binding
response to chemokine
cellular response to chemokine
protein homotetramerization
antimicrobial humoral response
liver development
growth cone
hepaticobiliary system development
digestive tract development
transmembrane signaling receptor activity
digestive system development
protein tetramerization
modification of morphology or physiology of other organism
regeneration