RENBP [The Human Chemical-Genetic Interaction Map Project]

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======= RENBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RENBP
  * **<color #00a2e8>Official Name</color>**: renin binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5973|5973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51606|P51606]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RENBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RENBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/312420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. {ECO:0000269|PubMed:9990133}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GlcNAc 2-epim|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acylglucosamine 2-epimerase activity|
|mannosamine metabolic process|
|N-acetylmannosamine metabolic process|
|N-acetylneuraminate catabolic process|
|UDP-N-acetylglucosamine biosynthetic process|
|N-acetylneuraminate metabolic process|
|amino sugar catabolic process|
|amino sugar biosynthetic process|
|peptidase inhibitor activity|
|UDP-N-acetylglucosamine metabolic process|
|N-acetylglucosamine metabolic process|
|nucleotide-sugar biosynthetic process|
|glucosamine-containing compound metabolic process|
|endopeptidase inhibitor activity|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|antibiotic catabolic process|
|antibiotic metabolic process|
|drug catabolic process|
|regulation of blood pressure|
|carbohydrate derivative catabolic process|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|negative regulation of proteolysis|
|blood circulation|
|circulatory system process|
|regulation of endopeptidase activity|
|small molecule catabolic process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|drug metabolic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.93|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RENBP Expression in NALM6 Cells: 2.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>