RENBP

Entrez Summary: The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. {ECO:0000269|PubMed:9990133}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
MKC9989 10μM R03 exp133	-1.93
BI-6727 0.001μM R01 exp42	2.1

N-acylglucosamine 2-epimerase activity
mannosamine metabolic process
N-acetylmannosamine metabolic process
N-acetylneuraminate catabolic process
UDP-N-acetylglucosamine biosynthetic process
N-acetylneuraminate metabolic process
amino sugar catabolic process
amino sugar biosynthetic process
peptidase inhibitor activity
UDP-N-acetylglucosamine metabolic process
N-acetylglucosamine metabolic process
nucleotide-sugar biosynthetic process
glucosamine-containing compound metabolic process
endopeptidase inhibitor activity
nucleotide-sugar metabolic process
amino sugar metabolic process
antibiotic catabolic process
antibiotic metabolic process
drug catabolic process
regulation of blood pressure
carbohydrate derivative catabolic process
negative regulation of endopeptidase activity
negative regulation of peptidase activity
carboxylic acid catabolic process
organic acid catabolic process
negative regulation of proteolysis
blood circulation
circulatory system process
regulation of endopeptidase activity
small molecule catabolic process
regulation of peptidase activity
negative regulation of hydrolase activity
drug metabolic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
regulation of proteolysis
negative regulation of catalytic activity
protein homodimerization activity
carboxylic acid metabolic process
oxoacid metabolic process