RGN
Gene Information
- Official Symbol: RGN
- Official Name: regucalcin
- Aliases and Previous Symbols: N/A
- Entrez ID: 9104
- UniProt: Q15493
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| SGL |
GO Terms
| negative regulation of aminoacyl-tRNA ligase activity |
| regulation of dUTP diphosphatase activity |
| gluconolactonase activity |
| regulation of calcium-dependent ATPase activity |
| regulation of leucine-tRNA ligase activity |
| positive regulation of dUTP diphosphatase activity |
| negative regulation of leucine-tRNA ligase activity |
| negative regulation of calcium-dependent ATPase activity |
| L-ascorbic acid biosynthetic process |
| negative regulation of ligase activity |
| regulation of aminoacyl-tRNA ligase activity |
| positive regulation of removal of superoxide radicals |
| positive regulation of superoxide dismutase activity |
| negative regulation of DNA catabolic process |
| regulation of superoxide dismutase activity |
| negative regulation of cilium-dependent cell motility |
| negative regulation of flagellated sperm motility |
| positive regulation of ATPase-coupled calcium transmembrane transporter activity |
| negative regulation of cyclic-nucleotide phosphodiesterase activity |
| positive regulation of response to reactive oxygen species |
| regulation of ligase activity |
| regulation of cyclic-nucleotide phosphodiesterase activity |
| water-soluble vitamin biosynthetic process |
| regulation of removal of superoxide radicals |
| negative regulation of bone development |
| regulation of ATPase-coupled calcium transmembrane transporter activity |
| L-ascorbic acid metabolic process |
| positive regulation of triglyceride biosynthetic process |
| regulation of DNA catabolic process |
| negative regulation of nitric oxide biosynthetic process |
| negative regulation of nitric oxide metabolic process |
| enzyme regulator activity |
| vitamin biosynthetic process |
| positive regulation of cellular response to oxidative stress |
| regulation of flagellated sperm motility |
| regulation of triglyceride biosynthetic process |
| positive regulation of triglyceride metabolic process |
| positive regulation of response to oxidative stress |
| negative regulation of ATPase activity |
| positive regulation of fatty acid biosynthetic process |
| regulation of bone development |
| regulation of cilium-dependent cell motility |
| negative regulation of reactive oxygen species biosynthetic process |
| liver regeneration |
| regulation of superoxide metabolic process |
| positive regulation of fatty acid metabolic process |
| positive regulation of phosphatase activity |
| regulation of response to reactive oxygen species |
| regulation of triglyceride metabolic process |
| positive regulation of glucose metabolic process |
| negative regulation of DNA biosynthetic process |
| positive regulation of calcium ion transmembrane transporter activity |
| regulation of fatty acid biosynthetic process |
| negative regulation of GTPase activity |
| monosaccharide biosynthetic process |
| positive regulation of oxidoreductase activity |
| negative regulation of reactive oxygen species metabolic process |
| positive regulation of ATPase activity |
| negative regulation of reproductive process |
| regulation of nitric oxide biosynthetic process |
| positive regulation of dephosphorylation |
| positive regulation of cellular carbohydrate metabolic process |
| negative regulation of phosphoprotein phosphatase activity |
| negative regulation of protein dephosphorylation |
| positive regulation of calcium ion transmembrane transport |
| animal organ regeneration |
| regulation of cellular response to oxidative stress |
| positive regulation of carbohydrate metabolic process |
| positive regulation of lipid biosynthetic process |
| regulation of ATPase activity |
| regulation of response to oxidative stress |
| regulation of reactive oxygen species biosynthetic process |
| regulation of fatty acid metabolic process |
| water-soluble vitamin metabolic process |
| regulation of calcium ion transmembrane transporter activity |
| positive regulation of reactive oxygen species metabolic process |
| regulation of oxidoreductase activity |
| regulation of calcium-mediated signaling |
| positive regulation of ion transmembrane transporter activity |
| negative regulation of phosphatase activity |
| positive regulation of transporter activity |
| negative regulation of dephosphorylation |
| regulation of DNA biosynthetic process |
| regulation of glucose metabolic process |
| regulation of phosphoprotein phosphatase activity |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| negative regulation of DNA metabolic process |
| positive regulation of calcium ion transport |
| negative regulation of epithelial cell proliferation |
| vitamin metabolic process |
| liver development |
| carbohydrate biosynthetic process |
| hepaticobiliary system development |
| coenzyme biosynthetic process |
| positive regulation of small molecule metabolic process |
| regulation of cellular carbohydrate metabolic process |
| regulation of protein dephosphorylation |
| positive regulation of cellular protein catabolic process |
| positive regulation of lipid metabolic process |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| regeneration |
| regulation of reproductive process |
| regulation of cellular ketone metabolic process |
| regulation of phosphatase activity |
| regulation of reactive oxygen species metabolic process |
| regulation of lipid biosynthetic process |
| monosaccharide metabolic process |
| positive regulation of transmembrane transport |
| regulation of carbohydrate metabolic process |
| regulation of dephosphorylation |
| cofactor biosynthetic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of protein catabolic process |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| regulation of calcium ion transport |
| regulation of cellular protein catabolic process |
| coenzyme metabolic process |
| negative regulation of cellular catabolic process |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| kidney development |
| negative regulation of cell motility |
| positive regulation of ion transport |
| negative regulation of transferase activity |
| regulation of transporter activity |
| aging |
| renal system development |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| negative regulation of cellular component movement |
| negative regulation of catabolic process |
| urogenital system development |
| negative regulation of locomotion |
| regulation of epithelial cell proliferation |
| regulation of cation transmembrane transport |
| regulation of neurotransmitter levels |
| regulation of DNA metabolic process |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| regulation of protein catabolic process |
| regulation of metal ion transport |
| regulation of lipid metabolic process |
| negative regulation of protein phosphorylation |
| gland development |
| positive regulation of GTPase activity |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| cellular calcium ion homeostasis |
| cofactor metabolic process |
| negative regulation of phosphorylation |
| calcium ion homeostasis |
| negative regulation of hydrolase activity |
| cellular divalent inorganic cation homeostasis |
| carbohydrate metabolic process |
| regulation of ion transmembrane transport |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| spermatogenesis |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| male gamete generation |
| small molecule biosynthetic process |
| negative regulation of protein modification process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| negative regulation of cell population proliferation |
| gamete generation |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of proteolysis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| zinc ion binding |
| multicellular organism reproduction |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of cell motility |
| negative regulation of developmental process |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of catabolic process |
| multi-organism reproductive process |
| negative regulation of cell death |
| oxoacid metabolic process |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| homeostatic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Beta-Estradiol 0.55μM R07 exp425 | -1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17683
- Expression level (log2 read counts): 0.4
Expression Distribution
RGN Expression in NALM6 Cells: 0.4
