RGP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RGP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RGP1
  * **<color #00a2e8>Official Name</color>**: RGP1 homolog, RAB6A GEF complex partner 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9827|9827]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92546|Q92546]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RGP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RGP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615742|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. {ECO:0000269|PubMed:23091056}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rgp1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RIC1-RGP1 guanyl-nucleotide exchange factor complex|
|Rab guanyl-nucleotide exchange factor activity|
|negative regulation of cellular protein catabolic process|
|retrograde transport, endosome to Golgi|
|trans-Golgi network membrane|
|negative regulation of protein catabolic process|
|cytosolic transport|
|Rab GTPase binding|
|endosomal transport|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|regulation of protein catabolic process|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|protein-containing complex|
|Golgi membrane|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|intracellular transport|
|positive regulation of molecular function|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-3.47|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.75|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.63|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.44|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.36|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.24|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.17|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.16|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.08|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-2.05|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.99|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.99|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.96|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.95|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.93|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.85|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.83|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.82|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.81|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.77|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.74|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.73|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.7|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.77|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.15|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kiaa1432|KIAA1432]]|0.542|
|[[:human genes:m:mbtps1|MBTPS1]]|0.514|
|[[:human genes:s:scap|SCAP]]|0.511|
|[[:human genes:g:gpr107|GPR107]]|0.458|
|[[:human genes:u:unc50|UNC50]]|0.453|
|[[:human genes:c:cept1|CEPT1]]|0.438|
|[[:human genes:w:wdr7|WDR7]]|0.426|
|[[:human genes:c:chka|CHKA]]|0.421|
|[[:human genes:c:cog5|COG5]]|0.413|
|[[:human genes:a:arl1|ARL1]]|0.402|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 40/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|2/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|1/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2800
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RGP1 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>