RGS1

Entrez Summary: N/A
UniProt Summary: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541). {ECO:0000250|UniProtKB:Q9JL25, ECO:0000269|PubMed:10480894, ECO:0000269|PubMed:18434541}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leukotriene signaling pathway
G-protein alpha-subunit binding
extrinsic component of cytoplasmic side of plasma membrane
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of G protein-coupled receptor signaling pathway
calmodulin binding
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GTPase activator activity
GTPase activity
positive regulation of GTPase activity
regulation of GTPase activity
response to bacterium
positive regulation of hydrolase activity
negative regulation of signal transduction
regulation of hydrolase activity
response to other organism
response to external biotic stimulus
G protein-coupled receptor signaling pathway
response to biotic stimulus
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
negative regulation of response to stimulus
positive regulation of molecular function
immune response