RGS3

Gene Information

Official Symbol: RGS3
Official Name: regulator of G protein signaling 3
Aliases and Previous Symbols: N/A
Entrez ID: 5998
UniProt: P49796
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10398
Expression level (log2 read counts): 2.62

Expression Distribution

C2
RGS
PDZ

inactivation of MAPK activity
negative regulation of MAP kinase activity
negative regulation of protein serine/threonine kinase activity
regulation of G protein-coupled receptor signaling pathway
negative regulation of MAPK cascade
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
GTPase activator activity
GTPase activity
regulation of MAP kinase activity
negative regulation of protein phosphorylation
positive regulation of GTPase activity
negative regulation of phosphorylation
regulation of GTPase activity
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of MAPK cascade
positive regulation of hydrolase activity
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
negative regulation of response to stimulus
positive regulation of molecular function
regulation of phosphate metabolic process