RHBDF1

Entrez Summary: N/A
UniProt Summary: Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
DOCK6	0.419
RPS6KA2	0.4

Rhomboid
Rhomboid SP

growth factor binding
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
negative regulation of protein secretion
negative regulation of peptide secretion
serine-type endopeptidase activity
negative regulation of protein transport
regulation of proteasomal protein catabolic process
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of proteolysis involved in cellular protein catabolic process
negative regulation of secretion
regulation of cellular protein catabolic process
regulation of protein catabolic process
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
cell population proliferation
Golgi membrane
regulation of protein transport
regulation of proteolysis
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
regulation of cellular catabolic process
endoplasmic reticulum membrane
cell migration
regulation of catabolic process
regulation of protein localization
localization of cell
cell motility
proteolysis
locomotion
protein transport
peptide transport
movement of cell or subcellular component
amide transport
establishment of protein localization
nitrogen compound transport