RHOD

Entrez Summary: N/A
UniProt Summary: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. {ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:24102721}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell division site
establishment or maintenance of actin cytoskeleton polarity
establishment or maintenance of cytoskeleton polarity
focal adhesion assembly
cell-substrate adherens junction assembly
lamellipodium assembly
adherens junction assembly
regulation of actin cytoskeleton reorganization
lamellipodium organization
cell-substrate junction assembly
regulation of cell-substrate junction assembly
regulation of focal adhesion assembly
actin filament bundle assembly
actin filament bundle organization
regulation of adherens junction organization
Rho protein signal transduction
adherens junction organization
regulation of cell junction assembly
regulation of cell-matrix adhesion
cell-matrix adhesion
cell cortex
regulation of cell shape
cell junction assembly
cell-substrate adhesion
establishment or maintenance of cell polarity
regulation of cell-substrate adhesion
endosome membrane
cell junction organization
actin filament organization
Ras protein signal transduction
early endosome
small GTPase mediated signal transduction
GTPase activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
protein targeting
regulation of actin filament-based process
GTP binding
positive regulation of cell adhesion
plasma membrane bounded cell projection assembly