RHOT2

Entrez Summary: This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]. COMPLETENESS: complete on the 3' end.
UniProt Summary: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). {ECO:0000250, ECO:0000269|PubMed:16630562}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial outer membrane permeabilization
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
integral component of mitochondrial outer membrane
establishment of mitochondrion localization, microtubule-mediated
mitochondrion transport along microtubule
positive regulation of mitochondrial membrane permeability
regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of membrane permeability
establishment of mitochondrion localization
mitochondrion localization
apoptotic mitochondrial changes
regulation of mitochondrial membrane permeability
Rho protein signal transduction
organelle transport along microtubule
regulation of membrane permeability
mitochondrial membrane organization
transport along microtubule
cytoskeleton-dependent intracellular transport
regulation of mitochondrion organization
microtubule-based transport
mitochondrial transport
Ras protein signal transduction
microtubule-based movement
apoptotic signaling pathway
small GTPase mediated signal transduction
GTPase activity
regulation of small GTPase mediated signal transduction
establishment of organelle localization
GTP binding
mitochondrion organization
organelle localization
microtubule-based process
calcium ion binding
membrane organization
cellular homeostasis
apoptotic process
programmed cell death
cell death
mitochondrion