RIMS1

Entrez Summary: The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C2
PDZ

acrosomal vesicle exocytosis
cytoskeleton of presynaptic active zone
positive regulation of inhibitory postsynaptic potential
modulation of inhibitory postsynaptic potential
presynaptic active zone cytoplasmic component
GTPase regulator activity
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of dendrite extension
acrosome reaction
regulation of dendrite extension
positive regulation of excitatory postsynaptic potential
glutamate secretion
presynaptic active zone
modulation of excitatory postsynaptic potential
calcium-ion regulated exocytosis
acidic amino acid transport
positive regulation of nervous system process
synaptic vesicle exocytosis
presynaptic membrane
regulation of synaptic vesicle exocytosis
dicarboxylic acid transport
acid secretion
neurotransmitter secretion
signal release from synapse
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
amino acid transport
synaptic vesicle cycle
ion channel binding
vesicle-mediated transport in synapse
membrane fusion
regulation of nervous system process
single fertilization
regulation of neurotransmitter transport
Rab GTPase binding
positive regulation of synaptic transmission
positive regulation of cell growth
regulation of regulated secretory pathway
signal release
fertilization