RIOK3

Gene Information

Official Symbol: RIOK3
Official Name: RIO kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 8780
UniProt: O14730
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in regulation of type I interferon (IFN)- dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). {ECO:0000269|PubMed:19557502, ECO:0000269|PubMed:22418843, ECO:0000269|PubMed:24807708, ECO:0000269|PubMed:25865883}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6440
Expression level (log2 read counts): 5.9

Expression Distribution

response to dsDNA
cellular response to dsDNA
negative regulation of MDA-5 signaling pathway
regulation of MDA-5 signaling pathway
negative regulation of protein homooligomerization
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
caspase binding
preribosome, small subunit precursor
negative regulation of protein oligomerization
regulation of protein homooligomerization
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
cellular response to dsRNA
negative regulation of defense response to virus
positive regulation of interferon-beta production
cellular response to virus
regulation of protein oligomerization
negative regulation of I-kappaB kinase/NF-kappaB signaling
maturation of SSU-rRNA
regulation of interferon-beta production
response to dsRNA
ribosomal small subunit biogenesis
regulation of defense response to virus
positive regulation of type I interferon production
negative regulation of response to biotic stimulus
negative regulation of immune effector process
regulation of type I interferon production
negative regulation of protein complex assembly
defense response to virus
negative regulation of defense response
rRNA processing
negative regulation of multi-organism process
rRNA metabolic process
regulation of I-kappaB kinase/NF-kappaB signaling
chromosome segregation
response to virus
ribosome biogenesis
positive regulation of innate immune response
positive regulation of response to biotic stimulus
protein serine/threonine kinase activity
negative regulation of response to external stimulus