RIT2
Gene Information
- Official Symbol: RIT2
- Official Name: Ras like without CAAX 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6014
- UniProt: Q99578
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. {ECO:0000250|UniProtKB:P70425}.
Pfam Domains GO Terms
Pfam Domains
| Miro |
| Arf |
| Ras |
GO Terms
| dendritic tree |
| regulation of Cdc42 protein signal transduction |
| semaphorin receptor binding |
| cell body |
| maintenance of protein location in cell |
| GDP binding |
| maintenance of location in cell |
| regulation of calcium-mediated signaling |
| maintenance of protein location |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| regulation of Rho protein signal transduction |
| cAMP-mediated signaling |
| negative regulation of neuron projection development |
| maintenance of location |
| cyclic-nucleotide-mediated signaling |
| negative regulation of cell projection organization |
| calmodulin binding |
| regulation of endocytosis |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| negative regulation of neuron differentiation |
| membrane raft |
| regulation of Ras protein signal transduction |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| Ras protein signal transduction |
| positive regulation of neuron projection development |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| small GTPase mediated signal transduction |
| neuron projection |
| GTPase activity |
| negative regulation of cell development |
| second-messenger-mediated signaling |
| regulation of small GTPase mediated signal transduction |
| positive regulation of neuron differentiation |
| MAPK cascade |
| positive regulation of cell projection organization |
| GTP binding |
| signal transduction by protein phosphorylation |
| chromatin binding |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| trans-synaptic signaling |
| synaptic signaling |
| positive regulation of neurogenesis |
| regulation of neuron projection development |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| regulation of MAPK cascade |
| regulation of neurogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| identical protein binding |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| phosphorylation |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Prochlorperazine 5.2μM R02 exp77 | 1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15155
- Expression level (log2 read counts): -7.68
Expression Distribution
RIT2 Expression in NALM6 Cells: -7.68
