RNASE2

Entrez Summary: N/A
UniProt Summary: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:3458170}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

induction of bacterial agglutination
lyase activity
ribonuclease activity
lipopolysaccharide binding
antibacterial humoral response
endonuclease activity
defense response to Gram-negative bacterium
azurophil granule lumen
defense response to Gram-positive bacterium
antimicrobial humoral response
RNA phosphodiester bond hydrolysis
defense response to virus
nucleic acid binding
RNA catabolic process
response to virus
nucleic acid phosphodiester bond hydrolysis
defense response to bacterium
humoral immune response
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
chemotaxis
taxis
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
response to bacterium
regulated exocytosis
leukocyte mediated immunity
exocytosis