RNF125 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF125 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF125
  * **<color #00a2e8>Official Name</color>**: ring finger protein 125
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54941|54941]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EQ8|Q96EQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF125&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF125|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610432|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). {ECO:0000269|PubMed:15843525, ECO:0000269|PubMed:17460044, ECO:0000269|PubMed:17643463, ECO:0000269|PubMed:25591766, ECO:0000269|PubMed:26027934, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:27411375}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|VCP-NPL4-UFD1 AAA ATPase complex|
|negative regulation of RIG-I signaling pathway|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|regulation of RIG-I signaling pathway|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|negative regulation of defense response to virus|
|ubiquitin conjugating enzyme binding|
|negative regulation of type I interferon production|
|p53 binding|
|regulation of defense response to virus|
|negative regulation of response to biotic stimulus|
|negative regulation of immune effector process|
|regulation of type I interferon production|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|ubiquitin protein ligase activity|
|negative regulation of cytokine production|
|protein polyubiquitination|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|negative regulation of intracellular signal transduction|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|adaptive immune response|
|cellular protein catabolic process|
|Golgi membrane|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|protein ubiquitination|
|regulation of cytokine production|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|zinc ion binding|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16324
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF125 Expression in NALM6 Cells: 3.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>