RNF125

Gene Information

Official Symbol: RNF125
Official Name: ring finger protein 125
Aliases and Previous Symbols: N/A
Entrez ID: 54941
UniProt: Q96EQ8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012].
UniProt Summary: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). {ECO:0000269|PubMed:15843525, ECO:0000269|PubMed:17460044, ECO:0000269|PubMed:17643463, ECO:0000269|PubMed:25591766, ECO:0000269|PubMed:26027934, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:27411375}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16324
Expression level (log2 read counts): 3.84

Expression Distribution

VCP-NPL4-UFD1 AAA ATPase complex
negative regulation of RIG-I signaling pathway
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
regulation of RIG-I signaling pathway
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
negative regulation of defense response to virus
ubiquitin conjugating enzyme binding
negative regulation of type I interferon production
p53 binding
regulation of defense response to virus
negative regulation of response to biotic stimulus
negative regulation of immune effector process
regulation of type I interferon production
negative regulation of defense response
negative regulation of multi-organism process
ubiquitin protein ligase activity
negative regulation of cytokine production
protein polyubiquitination
negative regulation of response to external stimulus
negative regulation of immune system process
regulation of innate immune response
regulation of immune effector process
negative regulation of intracellular signal transduction
regulation of response to biotic stimulus
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
adaptive immune response
cellular protein catabolic process
Golgi membrane
protein catabolic process
intracellular membrane-bounded organelle
protein ubiquitination
regulation of cytokine production
regulation of defense response
protein modification by small protein conjugation
regulation of multi-organism process
zinc ion binding
cellular macromolecule catabolic process