RNF138

Gene Information

Official Symbol: RNF138
Official Name: ring finger protein 138
Aliases and Previous Symbols: N/A
Entrez ID: 51444
UniProt: Q8WVD3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
UniProt Summary: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double- strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12989
Expression level (log2 read counts): 5.95

Expression Distribution

Screen	Score
ML-792 0.2μM R08 exp505	-2.17
Tubacin 1.6μM R07 exp416	1.8
Alda-1 10μM R06 exp262	2.31

zf-Nse
zf-C3HC4
zf-MIZ

DNA double-strand break processing involved in repair via single-strand annealing
double-strand break repair via single-strand annealing
DNA double-strand break processing
site of double-strand break
non-recombinational repair
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
double-strand break repair
ubiquitin protein ligase activity
DNA recombination
cell-cell signaling by wnt
Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
protein kinase binding
DNA repair
protein ubiquitination
DNA metabolic process
protein modification by small protein conjugation
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
cell-cell signaling
cellular response to stress