RNF139

Gene Information

Official Symbol: RNF139
Official Name: ring finger protein 139
Aliases and Previous Symbols: N/A
Entrez ID: 11236
UniProt: Q8WU17
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
UniProt Summary: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16051
Expression level (log2 read counts): 5.39

Expression Distribution

zf-C3HC4
zf-rbx1

ubiquitin-like protein transferase activity
Derlin-1 retrotranslocation complex
regulation of ER to Golgi vesicle-mediated transport
endoplasmic reticulum mannose trimming
protein alpha-1,2-demannosylation
protein demannosylation
endoplasmic reticulum quality control compartment
protein deglycosylation
protein destabilization
regulation of protein processing
regulation of protein maturation
endomembrane system
ERAD pathway
positive regulation of ubiquitin-dependent protein catabolic process
protease binding
positive regulation of proteolysis involved in cellular protein catabolic process
negative regulation of translation
positive regulation of cellular protein catabolic process
negative regulation of cellular amide metabolic process
regulation of ubiquitin-dependent protein catabolic process
signaling receptor activity
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
regulation of cellular protein catabolic process
response to endoplasmic reticulum stress
regulation of protein stability
proteasomal protein catabolic process
regulation of intracellular transport
regulation of translation
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
glycoprotein metabolic process
regulation of cellular amide metabolic process
positive regulation of catabolic process
posttranscriptional regulation of gene expression
regulation of vesicle-mediated transport
proteolysis involved in cellular protein catabolic process