RNF183 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF183 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF183
  * **<color #00a2e8>Official Name</color>**: ring finger protein 183
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=138065|138065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96D59|Q96D59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF183&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF183|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621029|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). {ECO:0000305|PubMed:26567849}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cis-Golgi network membrane|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|positive regulation of intrinsic apoptotic signaling pathway|
|protein autoubiquitination|
|regulation of response to endoplasmic reticulum stress|
|integral component of endoplasmic reticulum membrane|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|ubiquitin protein ligase activity|
|response to endoplasmic reticulum stress|
|protein polyubiquitination|
|lysosomal membrane|
|regulation of apoptotic signaling pathway|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein ubiquitination|
|positive regulation of cell death|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.501|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4842
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF183 Expression in NALM6 Cells: -1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>