RNF183

Entrez Summary: N/A
UniProt Summary: May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). {ECO:0000305|PubMed:26567849}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cis-Golgi network membrane
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of response to endoplasmic reticulum stress
positive regulation of intrinsic apoptotic signaling pathway
protein autoubiquitination
regulation of response to endoplasmic reticulum stress
integral component of endoplasmic reticulum membrane
regulation of intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
ubiquitin protein ligase activity
response to endoplasmic reticulum stress
protein polyubiquitination
lysosomal membrane
regulation of apoptotic signaling pathway
positive regulation of apoptotic process
positive regulation of programmed cell death
protein ubiquitination
positive regulation of cell death
regulation of cellular response to stress
protein modification by small protein conjugation
apoptotic process
protein modification by small protein conjugation or removal
endoplasmic reticulum
positive regulation of intracellular signal transduction
programmed cell death
cell death
regulation of response to stress
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
cellular response to stress
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction