RNF186

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein K29-linked ubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein K63-linked ubiquitination
protein autoubiquitination
protein localization to mitochondrion
intrinsic apoptotic signaling pathway
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
response to endoplasmic reticulum stress
apoptotic signaling pathway
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein localization to organelle
protein modification by small protein conjugation
cellular macromolecule catabolic process
apoptotic process
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
macromolecule catabolic process
programmed cell death
organonitrogen compound catabolic process
cell death
proteolysis
cellular protein localization
cellular macromolecule localization
intracellular signal transduction
cellular response to stress
organic substance catabolic process
cellular catabolic process