RNLS

Entrez Summary: N/A
UniProt Summary: Catalyzes the oxidation of the less abundant 1,2- dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta- NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:17385068, ECO:0000269|PubMed:25531177}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monoamine oxidase activity
NADH binding
oxidoreductase activity, acting on NAD(P)H
epinephrine binding
negative regulation of heart rate
NAD biosynthesis via nicotinamide riboside salvage pathway
response to epinephrine
response to salt
negative regulation of heart contraction
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
negative regulation of blood circulation
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
negative regulation of blood pressure
response to ischemia
oxidoreduction coenzyme metabolic process
regulation of heart rate
response to catecholamine
response to monoamine
coenzyme biosynthetic process
regulation of blood pressure
cofactor biosynthetic process
regulation of heart contraction
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
regulation of blood circulation
blood circulation
circulatory system process
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
regulation of system process
organophosphate metabolic process