RPL3
Gene Information
- Official Symbol: RPL3
- Official Name: ribosomal protein L3
- Aliases and Previous Symbols: N/A
- Entrez ID: 6122
- UniProt: P39023
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: The L3 protein is a component of the large subunit of cytoplasmic ribosomes. {ECO:0000305|PubMed:12962325}.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L3 |
GO Terms
| 5S rRNA binding |
| cellular response to interleukin-4 |
| ribosomal large subunit assembly |
| response to interleukin-4 |
| ribosome assembly |
| cytosolic large ribosomal subunit |
| ribosomal large subunit biogenesis |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| RNA catabolic process |
| establishment of protein localization to membrane |
| synapse |
| ribosome biogenesis |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| organic cyclic compound catabolic process |
| protein localization to membrane |
| amide biosynthetic process |
| peptide metabolic process |
| protein-containing complex |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| organelle assembly |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| nucleolus |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| cellular response to cytokine stimulus |
| macromolecule catabolic process |
| response to cytokine |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ATP6V1A | 0.406 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 730/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 25/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 15/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 19
- Expression level (log2 read counts): 10.29
Expression Distribution
RPL3 Expression in NALM6 Cells: 10.29
