RPL38 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL38 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL38
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L38
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6169|6169]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63173|P63173]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL38&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL38|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604182|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L38e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic 80S initiation complex|
|90S preribosome assembly|
|axial mesoderm development|
|middle ear morphogenesis|
|ribosomal small subunit assembly|
|ribosomal large subunit assembly|
|polysomal ribosome|
|ribosome assembly|
|cytosolic large ribosomal subunit|
|ribosomal small subunit biogenesis|
|ribosomal large subunit biogenesis|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|ear morphogenesis|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|mesoderm development|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|sensory perception of sound|
|protein targeting to membrane|
|sensory perception of mechanical stimulus|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ear development|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|postsynaptic density|
|sensory organ morphogenesis|
|ossification|
|establishment of protein localization to membrane|
|embryonic organ morphogenesis|
|ribosome biogenesis|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|embryonic organ development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|skeletal system development|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|sensory organ development|
|embryonic morphogenesis|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|intracellular protein transport|
|macromolecule catabolic process|
|nervous system process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.49|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.49|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.02|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.93|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.84|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.82|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.76|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.8|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.81|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.82|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.89|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.13|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl34|RPL34]]|0.494|
|[[:human genes:r:rpl35|RPL35]]|0.481|
|[[:human genes:r:rbbp5|RBBP5]]|0.473|
|[[:human genes:c:ckap5|CKAP5]]|0.467|
|[[:human genes:p:psmb4|PSMB4]]|0.463|
|[[:human genes:n:nup43|NUP43]]|0.462|
|[[:human genes:c:cactin|CACTIN]]|0.451|
|[[:human genes:p:ppie|PPIE]]|0.444|
|[[:human genes:b:brix1|BRIX1]]|0.436|
|[[:human genes:r:rps2|RPS2]]|0.434|
|[[:human genes:c:cdc73|CDC73]]|0.433|
|[[:human genes:z:zfand5|ZFAND5]]|0.432|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.431|
|[[:human genes:c:casc5|CASC5]]|0.429|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.428|
|[[:human genes:r:rbm39|RBM39]]|0.428|
|[[:human genes:r:rps28|RPS28]]|0.426|
|[[:human genes:p:pwp2|PWP2]]|0.424|
|[[:human genes:s:smg7|SMG7]]|0.424|
|[[:human genes:c:c19orf53|C19orf53]]|0.422|
|[[:human genes:b:bod1l1|BOD1L1]]|0.421|
|[[:human genes:c:cebpz|CEBPZ]]|0.421|
|[[:human genes:p:paf1|PAF1]]|0.42|
|[[:human genes:m:mdm2|MDM2]]|0.417|
|[[:human genes:p:pcf11|PCF11]]|0.417|
|[[:human genes:r:rrp15|RRP15]]|0.413|
|[[:human genes:i:ints6|INTS6]]|0.413|
|[[:human genes:r:riok2|RIOK2]]|0.411|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:w:wdr43|WDR43]]|0.408|
|[[:human genes:r:rps9|RPS9]]|0.406|
|[[:human genes:p:psmb1|PSMB1]]|0.405|
|[[:human genes:p:psmd1|PSMD1]]|0.405|
|[[:human genes:c:ctr9|CTR9]]|0.405|
|[[:human genes:s:stil|STIL]]|0.403|
|[[:human genes:p:pelp1|PELP1]]|0.402|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.401|
|[[:human genes:r:rsl1d1|RSL1D1]]|0.401|
|[[:human genes:l:lad1|LAD1]]|0.401|
|[[:human genes:r:rrp1|RRP1]]|0.4|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.4|
|[[:human genes:s:s1pr4|S1PR4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 490/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|20/28|
|bone|13/26|
|breast|22/33|
|central nervous system|41/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|13/21|
|liver|13/20|
|lung|41/75|
|lymphocyte|8/16|
|ovary|18/26|
|pancreas|13/24|
|peripheral nervous system|8/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|21/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1061
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL38 Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>