RPP14

Entrez Summary: N/A
UniProt Summary: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 501/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	18/28
blood	16/28
bone	18/26
breast	18/33
central nervous system	41/56
cervix	3/4
colorectal	10/17
esophagus	13/13
fibroblast	0/1
gastric	8/16
kidney	15/21
liver	14/20
lung	55/75
lymphocyte	12/16
ovary	15/26
pancreas	20/24
peripheral nervous system	12/16
plasma cell	6/15
prostate	0/1
skin	14/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	3/5

Expression Distribution

multimeric ribonuclease P complex
ribonuclease P RNA binding
ribonuclease P activity
tRNA 5-leader removal
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ncRNA processing
ncRNA metabolic process
nucleolus
RNA processing
RNA metabolic process
gene expression