RPS6KA1

Gene Information

Official Symbol: RPS6KA1
Official Name: ribosomal protein S6 kinase A1
Aliases and Previous Symbols: N/A
Entrez ID: 6195
UniProt: Q15418
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8403
Expression level (log2 read counts): 5.98

Expression Distribution

Pkinase
Pkinase Tyr
Pkinase C
Kdo

hepatocyte proliferation
epithelial cell proliferation involved in liver morphogenesis
positive regulation of hepatic stellate cell activation
liver morphogenesis
regulation of hepatic stellate cell activation
ribosomal protein S6 kinase activity
regulation of translation in response to stress
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
protein serine/threonine/tyrosine kinase activity
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
epithelial cell proliferation
negative regulation of cysteine-type endopeptidase activity
gland morphogenesis
regulation of DNA-templated transcription in response to stress
liver development
hepaticobiliary system development
positive regulation of cell growth
magnesium ion binding
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
positive regulation of growth
regulation of translation
negative regulation of proteolysis
protein serine/threonine kinase activity
regulation of cellular amide metabolic process
gland development
positive regulation of cell activation
regulation of cell growth
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
posttranscriptional regulation of gene expression
cell population proliferation
regulation of cell activation
regulation of growth
regulation of proteolysis
negative regulation of catalytic activity
negative regulation of apoptotic process