RPUSD3 [The Human Chemical-Genetic Interaction Map Project]

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======= RPUSD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPUSD3
  * **<color #00a2e8>Official Name</color>**: RNA pseudouridine synthase D3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=285367|285367]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P087|Q6P087]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPUSD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPUSD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617759|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that functions in the assembly of the mitochondrial ribosome by adding a pseudouridine group to 16S rRNA. Loss of this gene results in causes defects in mitochondrial protein production. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Major enzyme responsible for the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability. {ECO:0000269|PubMed:27974379}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PseudoU synth 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pseudouridine synthase activity|
|positive regulation of mitochondrial translation|
|pseudouridine synthesis|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|RNA modification|
|regulation of translation|
|mitochondrial matrix|
|regulation of cellular amide metabolic process|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.73|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.8|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.91|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.94|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.97|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.05|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.11|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa3|NDUFA3]]|0.623|
|[[:human genes:g:gfm2|GFM2]]|0.613|
|[[:human genes:l:lars2|LARS2]]|0.612|
|[[:human genes:q:qrsl1|QRSL1]]|0.61|
|[[:human genes:n:nars2|NARS2]]|0.603|
|[[:human genes:m:mrps21|MRPS21]]|0.597|
|[[:human genes:f:ftsj2|FTSJ2]]|0.593|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.587|
|[[:human genes:p:pet112|PET112]]|0.587|
|[[:human genes:n:ndufs2|NDUFS2]]|0.586|
|[[:human genes:n:ndufb11|NDUFB11]]|0.584|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.584|
|[[:human genes:m:mrpl21|MRPL21]]|0.577|
|[[:human genes:w:wbscr16|WBSCR16]]|0.577|
|[[:human genes:g:gfm1|GFM1]]|0.575|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.573|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.572|
|[[:human genes:m:malsu1|MALSU1]]|0.572|
|[[:human genes:a:aars2|AARS2]]|0.571|
|[[:human genes:n:ndufa1|NDUFA1]]|0.571|
|[[:human genes:n:ndufb6|NDUFB6]]|0.57|
|[[:human genes:f:fastkd2|FASTKD2]]|0.57|
|[[:human genes:d:dap3|DAP3]]|0.565|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.564|
|[[:human genes:m:mrps34|MRPS34]]|0.564|
|[[:human genes:c:cars2|CARS2]]|0.558|
|[[:human genes:r:rars2|RARS2]]|0.557|
|[[:human genes:d:dars2|DARS2]]|0.557|
|[[:human genes:p:pars2|PARS2]]|0.553|
|[[:human genes:y:yars2|YARS2]]|0.551|
|[[:human genes:g:grsf1|GRSF1]]|0.548|
|[[:human genes:r:rbfa|RBFA]]|0.546|
|[[:human genes:n:ndufa2|NDUFA2]]|0.545|
|[[:human genes:p:pet117|PET117]]|0.545|
|[[:human genes:m:mrps25|MRPS25]]|0.544|
|[[:human genes:s:selrc1|SELRC1]]|0.542|
|[[:human genes:m:mars2|MARS2]]|0.542|
|[[:human genes:r:rpusd4|RPUSD4]]|0.541|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.54|
|[[:human genes:m:mrps16|MRPS16]]|0.539|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.539|
|[[:human genes:c:c12orf65|C12orf65]]|0.537|
|[[:human genes:m:mrpl23|MRPL23]]|0.534|
|[[:human genes:e:eral1|ERAL1]]|0.531|
|[[:human genes:h:hars2|HARS2]]|0.531|
|[[:human genes:m:mto1|MTO1]]|0.531|
|[[:human genes:m:mrps26|MRPS26]]|0.53|
|[[:human genes:n:ndufb5|NDUFB5]]|0.529|
|[[:human genes:m:mcat|MCAT]]|0.529|
|[[:human genes:m:mettl17|METTL17]]|0.529|
|[[:human genes:m:mrpl47|MRPL47]]|0.528|
|[[:human genes:m:mrpl45|MRPL45]]|0.527|
|[[:human genes:m:mrpl15|MRPL15]]|0.527|
|[[:human genes:t:tfb1m|TFB1M]]|0.525|
|[[:human genes:m:mrps5|MRPS5]]|0.524|
|[[:human genes:c:coa6|COA6]]|0.523|
|[[:human genes:m:mterfd1|MTERFD1]]|0.521|
|[[:human genes:m:mrpl53|MRPL53]]|0.521|
|[[:human genes:n:ndufc2|NDUFC2]]|0.52|
|[[:human genes:m:mrps14|MRPS14]]|0.52|
|[[:human genes:n:nsun4|NSUN4]]|0.518|
|[[:human genes:e:ears2|EARS2]]|0.518|
|[[:human genes:p:pnpt1|PNPT1]]|0.513|
|[[:human genes:m:mrps27|MRPS27]]|0.512|
|[[:human genes:n:ndufa11|NDUFA11]]|0.512|
|[[:human genes:c:chchd1|CHCHD1]]|0.511|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.508|
|[[:human genes:m:mtif2|MTIF2]]|0.508|
|[[:human genes:t:tefm|TEFM]]|0.507|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.507|
|[[:human genes:n:ndufb9|NDUFB9]]|0.506|
|[[:human genes:v:vars2|VARS2]]|0.501|
|[[:human genes:n:ndufs5|NDUFS5]]|0.501|
|[[:human genes:m:mrps12|MRPS12]]|0.5|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.5|
|[[:human genes:m:mrpl49|MRPL49]]|0.498|
|[[:human genes:e:ecsit|ECSIT]]|0.498|
|[[:human genes:a:acad9|ACAD9]]|0.497|
|[[:human genes:m:mrp63|MRP63]]|0.496|
|[[:human genes:m:mrps6|MRPS6]]|0.496|
|[[:human genes:c:coa3|COA3]]|0.496|
|[[:human genes:c:cox16|COX16]]|0.495|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.495|
|[[:human genes:t:tmem261|TMEM261]]|0.494|
|[[:human genes:t:tars2|TARS2]]|0.492|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.492|
|[[:human genes:m:mtg1|MTG1]]|0.488|
|[[:human genes:m:mtg2|MTG2]]|0.487|
|[[:human genes:g:gatc|GATC]]|0.487|
|[[:human genes:a:atp5sl|ATP5SL]]|0.486|
|[[:human genes:s:ssbp1|SSBP1]]|0.485|
|[[:human genes:n:ndufa10|NDUFA10]]|0.484|
|[[:human genes:n:ndufc1|NDUFC1]]|0.483|
|[[:human genes:p:ptcd3|PTCD3]]|0.483|
|[[:human genes:m:mrpl20|MRPL20]]|0.482|
|[[:human genes:t:trub2|TRUB2]]|0.481|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.481|
|[[:human genes:m:mrpl17|MRPL17]]|0.48|
|[[:human genes:a:aifm1|AIFM1]]|0.478|
|[[:human genes:n:ndufv1|NDUFV1]]|0.476|
|[[:human genes:n:ndufs7|NDUFS7]]|0.475|
|[[:human genes:p:polg2|POLG2]]|0.474|
|[[:human genes:m:mrpl39|MRPL39]]|0.473|
|[[:human genes:m:mrps7|MRPS7]]|0.473|
|[[:human genes:f:fastkd5|FASTKD5]]|0.471|
|[[:human genes:s:slc25a26|SLC25A26]]|0.47|
|[[:human genes:m:mrpl43|MRPL43]]|0.47|
|[[:human genes:m:mrpl28|MRPL28]]|0.468|
|[[:human genes:d:ddx28|DDX28]]|0.468|
|[[:human genes:t:tufm|TUFM]]|0.467|
|[[:human genes:n:nubpl|NUBPL]]|0.465|
|[[:human genes:m:mrpl3|MRPL3]]|0.463|
|[[:human genes:n:ndufb7|NDUFB7]]|0.462|
|[[:human genes:f:fars2|FARS2]]|0.462|
|[[:human genes:f:foxred1|FOXRED1]]|0.461|
|[[:human genes:s:sco2|SCO2]]|0.46|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.46|
|[[:human genes:g:glrx5|GLRX5]]|0.46|
|[[:human genes:c:clpp|CLPP]]|0.46|
|[[:human genes:m:mrpl51|MRPL51]]|0.459|
|[[:human genes:p:pdss1|PDSS1]]|0.457|
|[[:human genes:p:polrmt|POLRMT]]|0.455|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.453|
|[[:human genes:m:mrpl4|MRPL4]]|0.452|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.447|
|[[:human genes:t:tomm6|TOMM6]]|0.447|
|[[:human genes:n:ndufs1|NDUFS1]]|0.447|
|[[:human genes:c:coq2|COQ2]]|0.444|
|[[:human genes:c:coq5|COQ5]]|0.444|
|[[:human genes:n:ndufs3|NDUFS3]]|0.442|
|[[:human genes:t:tomm20|TOMM20]]|0.442|
|[[:human genes:s:sars2|SARS2]]|0.442|
|[[:human genes:c:cox7b|COX7B]]|0.44|
|[[:human genes:c:cox15|COX15]]|0.439|
|[[:human genes:m:mrps33|MRPS33]]|0.438|
|[[:human genes:m:mrps22|MRPS22]]|0.435|
|[[:human genes:a:atp5c1|ATP5C1]]|0.434|
|[[:human genes:c:c1qbp|C1QBP]]|0.434|
|[[:human genes:m:mtif3|MTIF3]]|0.431|
|[[:human genes:n:ndufa8|NDUFA8]]|0.43|
|[[:human genes:m:mipep|MIPEP]]|0.43|
|[[:human genes:n:ndufa6|NDUFA6]]|0.427|
|[[:human genes:t:tfb2m|TFB2M]]|0.426|
|[[:human genes:m:mrpl12|MRPL12]]|0.425|
|[[:human genes:c:cox11|COX11]]|0.424|
|[[:human genes:h:higd2a|HIGD2A]]|0.423|
|[[:human genes:t:tomm22|TOMM22]]|0.423|
|[[:human genes:n:ndufb3|NDUFB3]]|0.423|
|[[:human genes:c:c17orf89|C17orf89]]|0.423|
|[[:human genes:h:hemk1|HEMK1]]|0.422|
|[[:human genes:l:lrpprc|LRPPRC]]|0.422|
|[[:human genes:n:noa1|NOA1]]|0.422|
|[[:human genes:m:mrps28|MRPS28]]|0.422|
|[[:human genes:a:atp5d|ATP5D]]|0.422|
|[[:human genes:i:iba57|IBA57]]|0.421|
|[[:human genes:b:bcs1l|BCS1L]]|0.42|
|[[:human genes:m:mrps18a|MRPS18A]]|0.419|
|[[:human genes:m:mrps11|MRPS11]]|0.419|
|[[:human genes:m:mtrf1|MTRF1]]|0.419|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.417|
|[[:human genes:m:mrps35|MRPS35]]|0.416|
|[[:human genes:m:mrps10|MRPS10]]|0.416|
|[[:human genes:m:mrpl18|MRPL18]]|0.415|
|[[:human genes:s:sfxn4|SFXN4]]|0.415|
|[[:human genes:p:polg|POLG]]|0.413|
|[[:human genes:m:mrps24|MRPS24]]|0.413|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.412|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.411|
|[[:human genes:p:prepl|PREPL]]|0.411|
|[[:human genes:m:mrpl22|MRPL22]]|0.411|
|[[:human genes:n:ndufb10|NDUFB10]]|0.411|
|[[:human genes:m:mrpl44|MRPL44]]|0.41|
|[[:human genes:n:ndufb4|NDUFB4]]|0.409|
|[[:human genes:s:slc25a3|SLC25A3]]|0.409|
|[[:human genes:w:wars2|WARS2]]|0.408|
|[[:human genes:c:c10orf2|C10orf2]]|0.407|
|[[:human genes:m:mrpl55|MRPL55]]|0.405|
|[[:human genes:c:cox19|COX19]]|0.404|
|[[:human genes:c:coq7|COQ7]]|0.402|
|[[:human genes:m:mrps23|MRPS23]]|0.402|
|[[:human genes:t:timm21|TIMM21]]|0.401|
|[[:human genes:m:mterfd2|MTERFD2]]|0.401|
|[[:human genes:c:cox17|COX17]]|0.401|
|[[:human genes:i:ict1|ICT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1835
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPUSD3 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>