RRAGB

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:9394008}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

guanyl ribonucleotide binding
Gtr1-Gtr2 GTPase complex
EGO complex
cellular response to leucine starvation
positive regulation of TORC1 signaling
GTPase binding
positive regulation of TOR signaling
regulation of TORC1 signaling
cellular response to amino acid starvation
response to amino acid starvation
cellular response to amino acid stimulus
regulation of TOR signaling
response to amino acid
cell cycle arrest
cellular response to starvation
regulation of macroautophagy
response to starvation
cellular response to acid chemical
cellular response to nutrient levels
lysosome
cellular response to extracellular stimulus
lysosomal membrane
GTPase activity
regulation of autophagy
cellular response to external stimulus
response to acid chemical
GTP binding
protein heterodimerization activity
response to nutrient levels
response to extracellular stimulus
negative regulation of cell cycle
cellular response to organonitrogen compound
cellular response to nitrogen compound
regulation of cellular catabolic process
regulation of catabolic process
cell cycle process
response to organonitrogen compound
positive regulation of intracellular signal transduction
cellular response to oxygen-containing compound
response to nitrogen compound