RSG1

Entrez Summary: N/A
UniProt Summary: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ras
Miro

regulation of vesicle fusion
ciliary basal body
regulation of exocytosis
GTPase activity
cilium assembly
cilium organization
GTP binding
plasma membrane bounded cell projection assembly
cell projection assembly
regulation of vesicle-mediated transport
regulation of secretion by cell
organelle assembly
exocytosis
regulation of secretion
secretion by cell
export from cell
secretion
plasma membrane bounded cell projection organization
cell projection organization
regulation of organelle organization
protein transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
nitrogen compound transport
regulation of transport
vesicle-mediated transport