RTP4

Entrez Summary: N/A
UniProt Summary: Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). {ECO:0000250|UniProtKB:Q9ER80, ECO:0000269|PubMed:16720576}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

olfactory receptor binding
protein insertion into membrane
detection of chemical stimulus involved in sensory perception of bitter taste
sensory perception of bitter taste
detection of chemical stimulus involved in sensory perception of taste
sensory perception of taste
protein targeting to membrane
defense response to virus
establishment of protein localization to membrane
response to virus
protein targeting
protein localization to membrane
detection of chemical stimulus involved in sensory perception
detection of chemical stimulus
sensory perception of chemical stimulus
detection of stimulus involved in sensory perception
cell surface
detection of stimulus
membrane organization
defense response to other organism
sensory perception
intracellular protein transport
immune effector process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
nervous system process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
system process