S100A14

Entrez Summary: N/A
UniProt Summary: Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chemokine receptor binding
positive regulation of monocyte chemotaxis
toll-like receptor 4 signaling pathway
positive regulation of mononuclear cell migration
regulation of monocyte chemotaxis
positive regulation of granulocyte chemotaxis
regulation of granulocyte chemotaxis
regulation of mononuclear cell migration
positive regulation of leukocyte chemotaxis
toll-like receptor signaling pathway
regulation of leukocyte chemotaxis
pattern recognition receptor signaling pathway
positive regulation of leukocyte migration
positive regulation of chemotaxis
regulation of leukocyte migration
regulation of chemotaxis
innate immune response-activating signal transduction
activation of innate immune response
nuclear body
response to lipopolysaccharide
response to molecule of bacterial origin
defense response to bacterium
positive regulation of innate immune response
positive regulation of response to biotic stimulus
calcium ion homeostasis
regulation of innate immune response
positive regulation of defense response
divalent inorganic cation homeostasis
positive regulation of cell migration
positive regulation of multi-organism process
positive regulation of cell motility
regulation of response to biotic stimulus
positive regulation of cellular component movement
cell junction
positive regulation of locomotion
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
metal ion homeostasis
activation of immune response