S1PR3

Gene Information

Official Symbol: S1PR3
Official Name: sphingosine-1-phosphate receptor 3
Aliases and Previous Symbols: N/A
Entrez ID: 1903
UniProt: Q99500
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13459
Expression level (log2 read counts): 4.59

Expression Distribution

7tm 1
7TM GPCR Srsx

negative regulation of endothelial cell development
negative regulation of establishment of endothelial barrier
sphingosine-1-phosphate receptor activity
negative regulation of endothelial cell differentiation
sphingosine-1-phosphate receptor signaling pathway
sphingolipid mediated signaling pathway
regulation of establishment of endothelial barrier
regulation of endothelial cell development
regulation of endothelial cell differentiation
negative regulation of epithelial cell differentiation
regulation of interleukin-1 beta production
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of interleukin-1 production
Notch signaling pathway
integrin binding
regulation of epithelial cell differentiation
cytokine production
lipid binding
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
negative regulation of cell development
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
regulation of cytokine production
cation homeostasis
negative regulation of cell differentiation
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
cellular homeostasis