SALL4

Entrez Summary: This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
UniProt Summary: Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. {ECO:0000269|PubMed:23012367}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inner cell mass cell proliferation
blastocyst growth
heterochromatin
somatic stem cell population maintenance
ventricular septum development
neural tube closure
tube closure
blastocyst development
primary neural tube formation
neural tube formation
cardiac septum development
embryonic epithelial tube formation
embryonic limb morphogenesis
embryonic appendage morphogenesis
cardiac ventricle development
epithelial tube formation
stem cell population maintenance
maintenance of cell number
morphogenesis of embryonic epithelium
tube formation
limb morphogenesis
appendage morphogenesis
neural tube development
cardiac chamber development
appendage development
limb development
epithelial tube morphogenesis
transcription factor binding
in utero embryonic development
developmental growth
growth
morphogenesis of an epithelium
heart development
cell population proliferation
tissue morphogenesis
embryonic morphogenesis
protein-containing complex
chordate embryonic development
embryo development ending in birth or egg hatching
tube morphogenesis