SCD5

Entrez Summary: N/A
UniProt Summary: Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nicotine 3000μM R08 exp510	1.8
Vitamin-D3 40μM R08 exp536	1.93

monounsaturated fatty acid biosynthetic process
stearoyl-CoA 9-desaturase activity
monounsaturated fatty acid metabolic process
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
unsaturated fatty acid biosynthetic process
acyl-CoA biosynthetic process
thioester biosynthetic process
ribonucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
fatty acid derivative biosynthetic process
thioester metabolic process
acyl-CoA metabolic process
unsaturated fatty acid metabolic process
fatty acid biosynthetic process
oxidoreductase activity
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
iron ion binding
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
fatty acid derivative metabolic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
monocarboxylic acid biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process