SCGB1A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SCGB1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCGB1A1
  * **<color #00a2e8>Official Name</color>**: secretoglobin family 1A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7356|7356]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11684|P11684]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCGB1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCGB1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Uteroglobin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polychlorinated biphenyl binding|
|response to silicon dioxide|
|response to ozone|
|negative regulation of interleukin-4 production|
|phospholipase A2 inhibitor activity|
|negative regulation of interleukin-5 production|
|negative regulation of interleukin-13 production|
|regulation of interleukin-13 production|
|regulation of interleukin-5 production|
|regulation of interleukin-4 production|
|negative regulation of interferon-gamma production|
|embryo implantation|
|rough endoplasmic reticulum|
|negative regulation of T cell proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|secretory granule|
|regulation of interferon-gamma production|
|negative regulation of T cell activation|
|response to fibroblast growth factor|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of lymphocyte activation|
|response to glucocorticoid|
|regulation of T cell proliferation|
|response to corticosteroid|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|nuclear envelope|
|regulation of mRNA stability|
|female pregnancy|
|regulation of RNA stability|
|response to reactive oxygen species|
|negative regulation of cell activation|
|regulation of mRNA catabolic process|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|regulation of leukocyte proliferation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|regulation of inflammatory response|
|response to acid chemical|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of lymphocyte activation|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|response to inorganic substance|
|regulation of leukocyte activation|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|regulation of catabolic process|
|multi-organism reproductive process|
|response to drug|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|regulation of immune system process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.28|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18843
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCGB1A1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>