SCGB1A1

Entrez Summary: This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010].
UniProt Summary: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.28
Docosahexaenoic-acid 50μM R07 exp356	-1.72

polychlorinated biphenyl binding
response to silicon dioxide
response to ozone
negative regulation of interleukin-4 production
phospholipase A2 inhibitor activity
negative regulation of interleukin-5 production
negative regulation of interleukin-13 production
regulation of interleukin-13 production
regulation of interleukin-5 production
regulation of interleukin-4 production
negative regulation of interferon-gamma production
embryo implantation
rough endoplasmic reticulum
negative regulation of T cell proliferation
negative regulation of mononuclear cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of leukocyte proliferation
secretory granule
regulation of interferon-gamma production
negative regulation of T cell activation
response to fibroblast growth factor
negative regulation of leukocyte cell-cell adhesion
negative regulation of lymphocyte activation
response to glucocorticoid
regulation of T cell proliferation
response to corticosteroid
negative regulation of cell-cell adhesion
negative regulation of leukocyte activation
nuclear envelope
regulation of mRNA stability
female pregnancy
regulation of RNA stability
response to reactive oxygen species
negative regulation of cell activation
regulation of mRNA catabolic process
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
multi-multicellular organism process
regulation of leukocyte proliferation
negative regulation of cell adhesion