SCN2B

Entrez Summary: The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015].
UniProt Summary: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to pyrethroid
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
regulation of atrial cardiac muscle cell membrane depolarization
voltage-gated sodium channel complex
response to insecticide
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during action potential
sodium channel regulator activity
regulation of heart rate by cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
voltage-gated ion channel activity
regulation of membrane depolarization
cardiac muscle cell action potential
membrane depolarization
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
cardiac muscle contraction
regulation of sodium ion transport
heart contraction
actin-mediated cell contraction
sodium ion transmembrane transport
cardiac conduction
action potential
regulation of heart rate
heart process
striated muscle contraction
actin filament-based movement
multicellular organismal signaling
sodium ion transport
regulation of heart contraction
muscle contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
regulation of blood circulation
muscle system process
regulation of cation transmembrane transport
regulation of metal ion transport
blood circulation