SCN3B [The Human Chemical-Genetic Interaction Map Project]

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======= SCN3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCN3B
  * **<color #00a2e8>Official Name</color>**: sodium voltage-gated channel beta subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55800|55800]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY72|Q9NY72]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCN3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCN3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608214|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|
|sodium channel inhibitor activity|
|regulation of ventricular cardiac muscle cell membrane depolarization|
|SA node cell to atrial cardiac muscle cell signaling|
|SA node cell action potential|
|regulation of atrial cardiac muscle cell membrane depolarization|
|SA node cell to atrial cardiac muscle cell communication|
|atrial cardiac muscle cell to AV node cell signaling|
|voltage-gated sodium channel complex|
|atrial cardiac muscle cell action potential|
|atrial cardiac muscle cell to AV node cell communication|
|membrane depolarization during cardiac muscle cell action potential|
|voltage-gated sodium channel activity|
|ventricular cardiac muscle cell action potential|
|positive regulation of heart rate|
|cell-cell signaling involved in cardiac conduction|
|membrane depolarization during action potential|
|sodium channel regulator activity|
|positive regulation of sodium ion transport|
|regulation of heart rate by cardiac conduction|
|positive regulation of heart contraction|
|cardiac muscle cell action potential involved in contraction|
|cardiac muscle cell contraction|
|cell communication involved in cardiac conduction|
|regulation of membrane depolarization|
|voltage-gated ion channel activity|
|cardiac muscle cell action potential|
|membrane depolarization|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|positive regulation of blood circulation|
|sensory perception of pain|
|cardiac muscle contraction|
|heart contraction|
|regulation of sodium ion transport|
|actin-mediated cell contraction|
|sodium ion transmembrane transport|
|cardiac conduction|
|action potential|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|ion channel binding|
|Z disc|
|multicellular organismal signaling|
|sodium ion transport|
|protein localization to plasma membrane|
|protein localization to cell periphery|
|regulation of heart contraction|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|ion homeostasis|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|positive regulation of transport|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6627
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCN3B Expression in NALM6 Cells: 2.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>