SCN3B

Gene Information

Official Symbol: SCN3B
Official Name: sodium voltage-gated channel beta subunit 3
Aliases and Previous Symbols: N/A
Entrez ID: 55800
UniProt: Q9NY72
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6627
Expression level (log2 read counts): 2.81

Expression Distribution

voltage-gated sodium channel activity involved in cardiac muscle cell action potential
sodium channel inhibitor activity
regulation of ventricular cardiac muscle cell membrane depolarization
SA node cell to atrial cardiac muscle cell signaling
SA node cell action potential
regulation of atrial cardiac muscle cell membrane depolarization
SA node cell to atrial cardiac muscle cell communication
atrial cardiac muscle cell to AV node cell signaling
voltage-gated sodium channel complex
atrial cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell communication
membrane depolarization during cardiac muscle cell action potential
voltage-gated sodium channel activity
ventricular cardiac muscle cell action potential
positive regulation of heart rate
cell-cell signaling involved in cardiac conduction
membrane depolarization during action potential
sodium channel regulator activity
positive regulation of sodium ion transport
regulation of heart rate by cardiac conduction
positive regulation of heart contraction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
cell communication involved in cardiac conduction
regulation of membrane depolarization
voltage-gated ion channel activity
cardiac muscle cell action potential
membrane depolarization
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
positive regulation of blood circulation
sensory perception of pain
cardiac muscle contraction
heart contraction
regulation of sodium ion transport
actin-mediated cell contraction
sodium ion transmembrane transport
cardiac conduction
action potential
regulation of heart rate