SCN7A
Gene Information
- Official Symbol: SCN7A
- Official Name: sodium voltage-gated channel alpha subunit 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 6332
- UniProt: Q01118
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011].
- UniProt Summary: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. {ECO:0000305}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11867
- Expression level (log2 read counts): 1.18
SCN7A Expression in NALM6 Cells: 1.18
