SCRT2

Gene Information

Official Symbol: SCRT2
Official Name: scratch family transcriptional repressor 2
Aliases and Previous Symbols: N/A
Entrez ID: 85508
UniProt: Q9NQ03
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17847
Expression level (log2 read counts): -2.69

Expression Distribution

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of neuron migration
E-box binding
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
negative regulation of apoptotic signaling pathway
nuclear chromatin
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II regulatory region sequence-specific DNA binding
regulation of apoptotic signaling pathway
DNA-binding transcription factor activity
regulation of neurogenesis
regulation of cell migration
negative regulation of transcription by RNA polymerase II
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of cell motility
regulation of nervous system development
regulation of cell development
regulation of locomotion
regulation of cellular component movement
negative regulation of cell death
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
regulation of apoptotic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death