SCUBE1 [The Human Chemical-Genetic Interaction Map Project]

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======= SCUBE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCUBE1
  * **<color #00a2e8>Official Name</color>**: signal peptide, CUB domain and EGF like domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80274|80274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWY4|Q8IWY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCUBE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCUBE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. {ECO:0000269|PubMed:16753137}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF 3|
|CUB|
|EGF|
|GCC2 GCC3|
|cEGF|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adult heart development|
|extrinsic component of plasma membrane|
|positive regulation of smoothened signaling pathway|
|extracellular matrix disassembly|
|regulation of smoothened signaling pathway|
|endothelial cell differentiation|
|post-embryonic development|
|endothelium development|
|blood coagulation|
|coagulation|
|hemostasis|
|protein homooligomerization|
|extracellular matrix organization|
|extracellular structure organization|
|external side of plasma membrane|
|cellular component disassembly|
|wound healing|
|protein heterodimerization activity|
|regulation of body fluid levels|
|inflammatory response|
|protein complex oligomerization|
|heart development|
|response to wounding|
|cell surface|
|epithelial cell differentiation|
|calcium ion binding|
|circulatory system development|
|identical protein binding|
|epithelium development|
|defense response|
|protein-containing complex assembly|
|extracellular space|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.71|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCUBE1 Expression in NALM6 Cells: 4.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>