SCUBE1

Entrez Summary: This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011].
UniProt Summary: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. {ECO:0000269|PubMed:16753137}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adult heart development
extrinsic component of plasma membrane
positive regulation of smoothened signaling pathway
extracellular matrix disassembly
regulation of smoothened signaling pathway
endothelial cell differentiation
post-embryonic development
endothelium development
blood coagulation
coagulation
hemostasis
protein homooligomerization
extracellular matrix organization
extracellular structure organization
external side of plasma membrane
cellular component disassembly
wound healing
protein heterodimerization activity
regulation of body fluid levels
inflammatory response
protein complex oligomerization
heart development
response to wounding
cell surface
epithelial cell differentiation
calcium ion binding
circulatory system development
identical protein binding
epithelium development
defense response
protein-containing complex assembly
extracellular space
positive regulation of signal transduction
tissue development
positive regulation of cell communication
positive regulation of signaling
protein-containing complex subunit organization