SEMA4C [The Human Chemical-Genetic Interaction Map Project]

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======= SEMA4C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA4C
  * **<color #00a2e8>Official Name</color>**: semaphorin 4C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54910|54910]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0C4|Q9C0C4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA4C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA4C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604462|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sema|
|PSI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell migration in hindbrain|
|neuropilin binding|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|negative regulation of axon guidance|
|regulation of axon extension involved in axon guidance|
|semaphorin-plexin signaling pathway|
|negative regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|neural crest cell migration|
|negative regulation of chemotaxis|
|synaptic vesicle membrane|
|negative regulation of axonogenesis|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|neural tube closure|
|tube closure|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|primary neural tube formation|
|cerebellum development|
|negative regulation of developmental growth|
|neural tube formation|
|regulation of extent of cell growth|
|metencephalon development|
|embryonic epithelial tube formation|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|hindbrain development|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|ameboidal-type cell migration|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|postsynaptic membrane|
|regulation of chemotaxis|
|mesenchyme development|
|negative regulation of neuron differentiation|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of growth|
|muscle cell differentiation|
|postsynaptic density|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|negative regulation of cell development|
|negative regulation of response to external stimulus|
|regulation of cellular component size|
|regulation of cell growth|
|morphogenesis of an epithelium|
|muscle structure development|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|cell junction|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|locomotion|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.71|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.91|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4499
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA4C Expression in NALM6 Cells: 2.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>